The protective effect of probiotics ( Lactobacillus acidophilus against urinary tract infections caused by Proteus mirabilis in vitro

Experiment studied the protective effect of probiotics bacteria Lactobacillus acidophilus against urinary tract infections in laboratory mice caused by Proteus mirabilis, by the preparation of heat-killed bacteriaLactobacillusacidophilus. 31 animals were divided into three groups, the first group contained five animals not treated, the second group contained five animals treated with the Lactobacillus acidophilus, in addition to the control group, which contained tow animals . The second group was injected over a five-day by (o.5) ml of stuck cells of heat killed L.acidophilus before challenge with 0.2 ml of the Proteus mirabilis (10 8 /cells per ml). The results showed that there was no evolution of infection with the Proteus mirabilis in the second group of animals, while injury has evolved significantly in the animals of first group non-treated with probiotic bacteria through not observing of the growth of the Proteus mirabilis on the culture media for blood and tissue samples taken from animals treated. A differential count of white blood cells results showed, an increase in the number of cells, particularly neutrophils in all the results examined. On the other hand study showed the results of the tissue sections of animals treated and non-treated for histological changes significantly for the untreated animals with the probiotics in compare with animals were simple changes.